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目的了解全血检测特异性抗结核抗体(LAM-IgG)对结核病快速诊断的价值。方法采受试者手指血20μL用金标试剂盒直接检测LAM-IgG。结果125例涂阳肺结核抗体阳性检出率为92.0%;267例涂阴肺结核抗体阳性检出率为78.3%;94例陈旧性肺结核抗体阳性检出率为75.5%;36例肺外结核抗体阳性检出率为83.3%;315例非结核抗体阳性检出率为47.6%。本试验灵敏度为82.7%(324/392),特异度为52.4%(165/315)。结论全血快速检测抗结核抗体较血清检测更方便,灵敏度高,但特异度较低,不能作为涂阴肺结核的最终诊断,此项检查可作为涂阴肺结核的辅助诊断和结核可疑者的筛选手段以及肺外结核的诊断指标之一。
Objective To understand the value of whole blood detection of specific anti-tuberculosis antibody (LAM-IgG) in the rapid diagnosis of tuberculosis. Methods Taken finger blood 20μL gold standard kit for direct detection of LAM-IgG. Results The positive rate of smear positive pulmonary tuberculosis in 125 cases was 92.0%. The positive rate of smear negative tuberculosis in 267 cases was 78.3%. The positive rate of 94 cases of old pulmonary tuberculosis was 75.5%. The positive rate of 36 cases of pulmonary tuberculosis was positive The detection rate was 83.3%. The positive rate of 315 non-tuberculosis antibodies was 47.6%. The test sensitivity was 82.7% (324/392), specificity was 52.4% (165/315). Conclusion The rapid detection of whole blood anti-TB antibody is more convenient and sensitive than the serum detection, but its specificity is low and can not be used as the final diagnosis of smear-negative pulmonary tuberculosis. This test can be used as a supplementary diagnosis of smear-negative pulmonary tuberculosis and a screening method of TB suspects As well as one of the diagnostic indicators of pulmonary tuberculosis.