本文报告甲巯丙脯酸治疗36例高血压病4周时总有效率86.1%。首次服药后15min降压,2h最明显,持续10h以上。用药后血浆肾素活性增高,血浆血管紧张素Ⅱ,醛固酮浓度及血管紧张素转换酶活性降低,并都在首次服药后2h变化最明显。用药4周时血浆心房利钠因子浓度下降。 This report reports the efficacy of captopril in 36 patients with hypertension at 4 weeks with a total effective rate of 86.1%. Antihypertensive 15min after the first dose, 2h most obvious, sustained 10h or more. After treatment, plasma renin activity increased, plasma angiotensin Ⅱ, aldosterone concentration and angiotensin converting enzyme activity decreased, and were the first 2h after taking the most obvious changes. 4 weeks after administration of plasma atrial natriuretic factor decreased.