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目的观察并对比不同剂量孕三烯酮治疗子宫腺肌病的临床疗效与安全性。方法选择110例子宫腺肌病患者随机分为A、B两组各55例,A组予每周口服孕三烯酮胶囊2次,每次2.5 mg,连续服用3个月;B组予每周口服孕三烯酮胶囊3次,每次2.5 mg,连续服用1个月。服药期间记录药物不良反应,服药结束后3、6个月对比两组月经量PBAC评分、痛经VRS评分,服药结束后6个月比较两组子宫体大小。结果 A组治疗后3、6个月PBAC评分(84.8±15.9、65.7±11.4)与VRS评分(1.8±0.5、1.4±0.4)均略低于B组(88.0±17.3、68.9±12.0;1.9±0.5、1.5±0.5),差异无统计学意义(P>0.05);A组治疗后6个月子宫体缩小程度达到显效比例(20.0%)略高于B组(16.4%),差异无统计学意义(P>0.05)。A组服药期间胃肠道反应(16.4%)、不规则阴道出血(16.4%)与肝功异常比例(14.5%)高于B组(10.9%、12.7%、7.3%),差异无统计学意义(P>0.05)。结论孕三烯酮A、B两组的疗程方案用于治疗子宫腺肌病的疗效相当,且后者能一定程度降低不良反应发生率。
Objective To observe and compare the clinical efficacy and safety of different doses of gestrinone in the treatment of adenomyosis. Methods A total of 110 cases of adenomyosis were randomly divided into two groups (A and B), 55 cases in each group. Group A received gestrinone capsule twice a week for 2.5 mg each for 3 months. Group B Weeks gestrinone capsules 3 times, each 2.5 mg, taking 1 month. Drug adverse reactions were recorded during the medication, 3,6 months after the end of the two groups compared the amount of menstrual flow PBAC score, dysmenorrhea VRS score, 6 months after the end of the dose comparison of two groups of uterine body size. Results The PBAC scores (84.8 ± 15.9, 65.7 ± 11.4) and VRS scores (1.8 ± 0.5, 1.4 ± 0.4) in group A at 3 and 6 months after treatment were lower than those in group B (88.0 ± 17.3,68.9 ± 12.0 and 1.9 ± 0.5,1.5 ± 0.5), the difference was not statistically significant (P> 0.05); A group of 6 months after treatment to reduce the extent of the uterus to achieve significant (20.0%) slightly higher than the B group (16.4%), the difference was not statistically significant Significance (P> 0.05). Gastrointestinal reaction (16.4%), irregular vaginal bleeding (16.4%) and abnormal liver function (14.5%) in group A were significantly higher than those in group B (10.9%, 12.7% and 7.3%, respectively) (P> 0.05). Conclusions Gestrinone A and B treatment regimens for the treatment of adenomyosis have similar efficacy, and the latter can reduce the incidence of adverse reactions to a certain extent.