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人类近端着丝粒染色体随体联合(SA)是指在有丝分裂中期的细胞内,D、G 组染色体以随体端相向聚集的现象。一般认为,SA 频率增高可能会导致先天愚型患儿的出生风险增高。1966年,Fialkow 等人发现甲状腺疾病和先天愚型患儿的出生风险增高有关。Nilsson 等人的研究结果也表明,先天愚型患儿的母亲患甲状腺机能亢进(甲亢)的风险增高,而且甲亢患者的SA 频率显著增高。另外,用甲亢患者血清代替培养液中的小牛血清
Human proximal centromere chromosomes satellite association (SA) refers to the metaphase cells in the mitochondria, D, G group of chromosomes with the body side of the phenomenon of aggregation. It is generally believed that an increase in the frequency of SA may result in an increased risk of birth in children with Down’s syndrome. In 1966, Fialkow et al. Found that thyroid disease is associated with an increased risk of birth in children with Down’s syndrome. Nilsson et al’s findings also show that mothers of children with Down’s syndrome have a higher risk of hyperthyroidism (hyperthyroidism), and that the frequency of SA in patients with hyperthyroidism is significantly higher. In addition, patients with hyperthyroidism serum instead of culture medium bovine serum