Objective To investigate the Bmil protein level in human colorectal cancer specimen and associated clinico-pathological parameters,and to determine the influence of Bmil on the proliferation and apoptosis of colorectal cancer cells. Methods Bmi1 protein level was assessed in 85 patients with colorectal cancer and adjacent normal tissue by immunohistochemistry. Objective To investigate the Bmil protein level in human colorectal cancer specimen and associated clinico-pathological parameters, and to determine the influence of Bmil on the proliferation and apoptosis of colorectal cancer cells. Methods Bmi1 protein level was assessed in 85 patients with colorectal cancer and adjacent Normal tissue by immunohistochemistry.