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目的研究氟比洛芬口崩片在兔体内的药代动力学特征。方法6只受试兔随机分成2组:单剂量交叉口服氟比洛芬口崩片1片(50mg/片)和普通片1片(50mg/片),于一定时间采集血样,用高效液相色谱法测定24h内的血浆药物浓度。采用DAS2.0软件对有关参数进行方差分析。结果氟比洛芬口崩片和普通片T1/2(h)分别为(7.072±1.102)和(6.338±1.913),Cmax(μg/ml)分别为(11.473±0.542)和(11.558±0.437),Tmax(h)分别为(0.292±0.102)和(0.917±0.129),AUC(0-t)(μg/ml·h)分别为(77.441±10.677)和(76.741±11.890),AUC(0-∞)(μg/ml·h)分别为(84.836±12.588)和(83.305±16.980)。氟比洛芬口崩片平均相对生物利用度为102.7%。结论氟比洛芬口崩片与普通片具有生物学等效性。
Objective To study the pharmacokinetics of flurbiprofen orally disintegrating tablets in rabbits. Methods Six rabbits were randomly divided into two groups: a single oral dose of flurbiprofen orally disintegrating tablets (50mg / tablet) and a common tablet (50mg / tablet), at a certain time to collect blood samples with high performance liquid Determination of plasma drug concentration within 24h by chromatography. Using DAS2.0 software on the parameters of variance analysis. Results The levels of flurbiprofen orally disintegrating tablets and common tablets were (7.072 ± 1.102) and (6.338 ± 1.913), respectively, and Cmax (μg / ml) were 11.473 ± 0.542 and 11.558 ± 0.437, respectively , Tmax (h) were (0.292 ± 0.102) and (0.917 ± 0.129) and AUC (0-t) were respectively (77.441 ± 10.677) and (76.741 ± 11.890) ∞) (μg / ml · h) were (84.836 ± 12.588) and (83.305 ± 16.980), respectively. The average relative bioavailability of flurbiprofen orally disintegrating tablets was 102.7%. Conclusion Flurbiprofen orally disintegrating tablets and tablets are bioequivalent.