论文部分内容阅读
目的:探讨中药姬松茸菌孢多糖对胃癌大鼠ΜΦ、IL-1的影响及其抑瘤作用。方法:将Wistar大鼠随机分为5组:除空白对照组外,其余4组均经免疫抑制处理(注射阿糖胞苷与60Co全身照射)后,皮下接种胃癌细胞悬液,制成胃癌大鼠模型。其中3组分别用姬松茸菌孢多糖大、小剂量及香菇多糖灌胃治疗,空白和模型对照组分别用相等剂量的生理盐水灌胃。10天后,观察各组肿瘤生长情况及相关免疫指标ΜΦ活性、IL-1含量。结果:胃癌大鼠模型组与正常对照组比较,ΜΦ吞噬功能、IL-1含量均显著降低(P<0.01),经香菇多糖和姬松茸菌孢多糖治疗后,腹腔ΜΦ吞噬功能、IL-1含量均显著提高(P<0.01),瘤块明显减小(P<0.01);且姬松茸菌孢多糖组的治疗效果优于香菇多糖组(P<0.05)。结论:姬松茸菌孢多糖有促进胃癌大鼠免疫功能及抑制肿瘤生长的作用。
OBJECTIVE: To investigate the effects of polysaccharides of Agaricus blazei on the ΜΦ, IL-1 of gastric cancer rats and its antitumor effect. Methods: Wistar rats were randomly divided into 5 groups: In addition to the blank control group, the remaining 4 groups were treated with immunosuppressive treatment (after injecting cytarabine and 60Co total body irradiation) and subcutaneously inoculated with a suspension of gastric cancer cells to obtain gastric cancer. Mouse model. Three of the three groups were treated with large and small doses of polysaccharides of Agaricus blazei spp. and lentinan, respectively. The blank and model control groups were intragastrically administered with equal doses of normal saline, respectively. After 10 days, the tumor growth and related immune parameters ΜΦ activity and IL-1 content were observed in each group. RESULTS: Compared with the normal control group, the phagocytosis of ΜΦ and the content of IL-1 in the gastric cancer rat model group were significantly decreased (P<0.01). After treatment with lentinan and Agaricus blazei spore polysaccharide, the peritoneal Μ phagocytosis function, IL-1 The contents of the strains were significantly increased (P<0.01), and the tumor mass was significantly reduced (P<0.01). The treatment effect of the strain of Agaricus blazei spore polysaccharide was superior to that of lentinan group (P<0.05). Conclusion: Polysaccharides of Agaricus blazei spores can promote the immune function of gastric cancer rats and inhibit the growth of tumors.