胰高血糖素样肽-1(GLP-1)由胰岛α细胞和肠道L细胞分泌,具有葡萄糖依赖性促胰岛素分泌、抑制胰高血糖素产生、增加β细胞数量及延缓胃排空等作用。易被二肽基肽酶Ⅳ(DPP-Ⅳ)降解,半衰期(t12)仅数分钟。近来,GLP-1类似物和DPP-Ⅳ抑制剂的研发为2型糖尿病的治疗提供了新策略。 Glucagon-like peptide-1 (GLP-1) is secreted by pancreatic α cells and intestinal L cells and has the effects of glucose-dependent insulin secretion, inhibition of glucagon production, increase of β cell number and delayed gastric emptying . It is easily degraded by dipeptidyl peptidase IV (DPP-IV) with a half-life (t12) of only a few minutes. Recently, the development of GLP-1 analogs and DPP-IV inhibitors has provided a new strategy for the treatment of type 2 diabetes.