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特发性扩张型心肌病(IDC)伴心功能不全患者存在心肌细胞膜β-受体密度减低的生化缺陷,但其发生机理尚不明确。近来作者观察到较多的 IDC 患者血清中存在抗β-受体抗体,因此考虑这种自身抗体很可能在β-受体异常方面起中介作用。因为发现仅在心肌病的一个亚型即 IDC 患者血清中抗β-受体抗体滴度较高,所以本文研究这种自身抗体的存在与决定 IDC 易患性的免疫遗传因素是否有关。方法该研究以100例 IDC 患者(100
Patients with idiopathic dilated cardiomyopathy (IDC) with congestive heart failure have reduced biochemical deficits in myocardial cell membrane beta-receptor density, but its mechanism of action is unclear. Recently, the authors observed that there is more anti-beta -receptor antibody in the serum of IDC patients, so it is likely that this autoantibody may play an intermediate role in beta -receptor abnormality. Because it was found that the titers of anti-beta-receptor antibodies were high only in the sera of IDC patients, a subtype of cardiomyopathy, this study examined whether the presence of this autoantibody is associated with the immune genetic determinants of IDC susceptibility. Methods The study enrolled 100 IDC patients (100