论文部分内容阅读
目的探讨白细胞分化抗原14(CD14)基因启动子区-1145A/G、-159C/T多态性与重庆地区严重胸部创伤(SCT)患者并发多器官功能障碍综合征(MODS)的相关性。方法采用限制性片段长度多态性-聚合酶链式反应技术,检测106例SCT患者(其中47例并发MODS)CD14基因启动子区-159C/T、-1145A/G单核苷酸多态性位点基因型。结果 -1145G等位基因携带者并发MODS的可能性显著高于A等位基因携带者(P=0.033),G等位基因携带者MODS评分显著高于A等位基因携带者(显性遗传模式P=0.217,隐性遗传模式P=0.037)。-159T等位基因携带者MODS评分显著高于C等位基因携带者(显性遗传模式P=0.048,隐性遗传模式P=0.198)。-1145、-159等位基因型与MODS评分呈线性相关(P=0.043,P=0.046)。两个位点同时发生突变与只有1个位点发生突变的患者相比,MODS发生率差异有统计学意义(P<0.01),MODS评分差异无统计学意义(P=0.239)。结论 CD14基因启动子区-1145 A/G、-159C/T多态性与重庆地区汉族SCT患者并发MODS有相关性。
Objective To investigate the association of -145A / G and -159C / T polymorphisms in the promoter region of leukocyte differentiation antigen 14 (CD14) gene with multiple organ dysfunction syndrome (MODS) in patients with severe chest trauma (SCT) in Chongqing. Methods The restriction fragment length polymorphism (PCR) and polymerase chain reaction (PCR) were used to detect the single nucleotide polymorphisms of -159C / T and -1145A / G in the promoter region of CD14 gene in 106 patients with SCT (47 patients with MODS) Site genotypes. Results The odds of complicated MODS with -1145G allele were significantly higher than those with allele A (P = 0.033). The MODS scores of G allele were significantly higher than those with allele A (dominant inheritance pattern P = 0.217, recessive mode P = 0.037). The MODS score of -159T allele was significantly higher than that of C allele (dominant genetic model P = 0.048, recessive genetic model P = 0.198). The -1145 and -159 alleles were linearly correlated with MODS scores (P = 0.043, P = 0.046). There were significant differences in the incidence of MODS (P <0.01) and no significant difference in MODS scores (P = 0.239) between patients with and without mutations at one locus. Conclusion The polymorphisms of -145 A / G and -159C / T in CD14 gene promoter region are associated with MODS in Han Chinese with SCT in Chongqing area.