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目的:探讨脑源性神经营养因子(Brain-derived neurotrophic factor,BDNF)与2型糖尿病(Diabetes mellitus type2,T2DM)及糖尿病周围神经病变(Diabetic peripheral neuropathy,DPN)的相关性研究。方法:纳入T2DM及DPN患者各45例,分别对两组患者血压、血糖、血脂、胰岛素抵抗指数(HOMA-IR)、BDNF等指标进行对比分析。对两组患者BDNF表达水平变化的相关因素进行Pearson相关分析以及多因素线性回归分析。结果:DPN组病程、FBG、HOMA-IR、BDNF分别为(12.16±5.84)年、(10.24±3.93)mmol/L、(3.75±2.02)、(3.43±0.94),T2DM组病程、FBG、HOMA-IR、BDNF分别为(7.43±5.29)年、(8.19±3.35)mmol/L、(2.69±1.84)、(4.91±1.67),差异有显著性(P<0.05);多因素线性回归分析显示,病程、感觉阈值与BDNF表达水平相关(P<0.05);Pearson相关分析显示,BDNF表达水平与HOMA-IR存在显著负相关(P<0.05)。结论:DPN患者BDNF水平明显降低,其水平与感觉阈值、病程、HOMA-IR呈现负相关。
Objective: To investigate the correlation between brain derived neurotrophic factor (BDNF) and type 2 diabetes mellitus (T2DM) and diabetic peripheral neuropathy (DPN). Methods: Forty-five patients with T2DM and DPN were included in this study. Blood pressure, blood glucose, lipids, insulin resistance index (HOMA-IR) and BDNF were compared between the two groups. Pearson correlation analysis and multivariate linear regression analysis were performed on the related factors of BDNF expression in both groups. Results: The course of disease, FBG, HOMA-IR and BDNF in DPN group were (12.16 ± 5.84) years, (10.24 ± 3.93) mmol / L, (3.75 ± 2.02) and (3.43 ± 0.94) -IR and BDNF were (7.43 ± 5.29) years, (8.19 ± 3.35) mmol / L, (2.69 ± 1.84) and (4.91 ± 1.67) respectively, with significant difference (P <0.05). Multivariate linear regression analysis (P <0.05). The Pearson correlation analysis showed that there was a significant negative correlation between the expression of BDNF and HOMA-IR (P <0.05). Conclusion: The level of BDNF in patients with DPN is significantly lower than that in patients with DPN. The level of BDNF is negatively correlated with the sensory threshold, duration of disease and HOMA-IR.