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目的研究不同剂量米非司酮对子宫肌瘤的治疗效果。方法选取我院2013年1月至2014年6月门诊及住院部收治的86例子宫肌瘤患者为研究对象,根据药物治疗剂量的不同将其分为两组,每组43例,两组患者均进行米非司酮治疗,观察组患者给予12.5 mg/d治疗,对照组患者给予25.0 mg/d治疗,对比分析两组患者的临床治疗效果。结果两组患者治疗后子宫体积、肌瘤体积、FSH、LH、E2、P等激素水平的比较t=2.9689、6.8606、6.7109、7.1402、5.7487、8.1311;不良反应发生情况比较χ2=4.4775,P均<0.05,差异具有统计学意义。在血红蛋白水的比较上,P>0.05,差异无统计学意义。结论米非司酮对子宫肌瘤的治疗效果显著,大剂量和小剂量的治疗均可缓解患者临床症状、减小肌瘤体积,但小剂量治疗安全性更高,可作为临床对子宫肌瘤药物保守治疗的首选方式。
Objective To study the therapeutic effect of different doses of mifepristone on uterine fibroids. Methods Totally 86 patients with uterine fibroids in our hospital from January 2013 to June 2014 were enrolled and divided into two groups according to the dosage of drug, 43 patients in each group, two groups of patients Were treated with mifepristone, 12.5 mg / d in the observation group and 25.0 mg / d in the control group. The clinical effects of the two groups were compared. Results After treatment, the uterine volume, fibroids volume, FSH, LH, E2, P and other hormone levels in the two groups were compared as t = 2.9689,6.8606,6.7109,7.1402,5.7487,8.1311; the incidence of adverse reactions was χ2 = 4.4775, P <0.05, the difference was statistically significant. In the comparison of hemoglobin, P> 0.05, the difference was not statistically significant. Conclusion Mifepristone treatment of uterine fibroids significant effect, high-dose and low-dose treatment can alleviate the clinical symptoms and reduce fibroid volume, but the safety of small doses of higher treatment, can be used as clinical uterine fibroids The preferred method of conservative treatment of drugs.