甲巯丙脯酸为血管紧张素转化酶抑制剂,用来治疗高血压病和心力衰竭。常有皮肤反应,发生在治疗高血压中约为12%,包括有血管性水肿、瘙痒性斑丘疹、玫瑰糠疹样皮疹、轻度毒性红斑和剥脱性皮炎。本文报告了4例用小剂量甲巯丙脯酸治疗心力衰竭出现严重的皮肤反应。4例中男3、女1,年龄57～80岁,应用甲巯丙脯酸75mg/d治疗心力衰竭。投药后3～6周,在手、臂、面部等处发生皮疹,呈荨麻疹样红斑、湿疹样皮疹,并于短期内扩展,变为红皮病,停药后持续4～6周才消退。 Captopril is an angiotensin-converting enzyme inhibitor used to treat hypertension and heart failure. Often there is a skin reaction that occurs in about 12% of the treatment of hypertension, including angioedema, pruritic rash, rose pityriasis rash, mildly toxic erythema and exfoliative dermatitis. This article reports four patients who experienced severe skin reactions with low-dose captopril in the treatment of heart failure. 4 cases of male 3, female 1, aged 57 to 80 years, the application of captopril 75mg / d treatment of heart failure. 3 to 6 weeks after administration, a rash on the hands, arms, face and the like occurs in the form of urticaria-like erythema and eczematous rash and spreads in a short period of time to become erythroderma. The withdrawal persists for 4 to 6 weeks .