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大多数Gα_(i/o)偶联受体(Gαi/o-coupled receptors)在持续激活条件下能够导致细胞内腺苷酸环化酶(adenylyl cyclase,AC)活性增强和随后的环腺苷酸(cyclic adenosine monophosphate,c AMP)浓度增加,通常将这种现象称作AC“超敏化(supersensitization)”。它是一种细胞适应性反应机制,普遍认为是造成药物依赖性的原因。AC“超敏化”可能在精神病和抑郁症等许多由于细胞功能的改变而引起的中枢神经系统紊乱疾病(CNS disorder diseases)中发挥重要影响。本文对Gα_(i/o)偶联受体介导AC“超敏化”的研究历史与现状进行了综述,并讨论了存在的问题与未来展望。
The majority of Gα / (i / o) coupled receptors (Gαi / o-coupled receptors) under sustained activation conditions can lead to increased intracellular adenylyl cyclase (ACY) activity and subsequent cyclic adenosine monophosphate (c AMP) concentration increases, this phenomenon is often referred to as AC “supersensitization (supersensitization) ”. It is a cellular adaptive response mechanism, generally believed to be the cause of drug dependence. AC “hypersensitivity ” may play an important role in many CNS disorder diseases, such as psychosis and depression, due to changes in cellular functions. This review summarizes the history and current status of Gα_ (i / o) coupled receptor mediated AC “hypersensitivity ” and discusses the existing problems and future prospects.