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目的:探讨c-K it蛋白的表达与小细胞肺癌(SCLC)发生、发展的关系。方法:应用免疫组化SABC法检测65例手术切除SCLC、癌旁组织和正常肺组织中,c-K it蛋白的表达。结果:SCLC中c-K it蛋白阳性表达率明显高于正常肺组织和癌旁组织(P<0.05)。c-K it蛋白的表达与肿瘤大小以及预后生存期密切相关(P<0.05)。与SCLC患者性别、年龄、淋巴结转移情况无明显相关(P>0.05)。结论:c-K it蛋白的表达与SCLC的发生、发展及肿瘤大小及预后密切相关。
Objective: To investigate the relationship between the expression of c-Kit protein and the occurrence and development of small cell lung cancer (SCLC). Methods: Immunohistochemical SABC method was used to detect the expression of c-Kit protein in 65 cases of resected SCLC, adjacent non-cancerous tissues and normal lung tissues. Results: The positive rate of c-Kit protein expression in SCLC was significantly higher than that in normal lung tissues and adjacent normal tissues (P <0.05). The expression of c-Kit protein was closely related to tumor size and prognosis (P <0.05). There was no significant correlation between SCLC patients’ gender, age and lymph node metastasis (P> 0.05). Conclusion: The expression of c-Kit protein is closely related to the occurrence and development of SCLC and tumor size and prognosis.