论文部分内容阅读
目的探讨预防性葛根素对UVB诱导的HaCa T细胞凋亡的影响。方法 HaCa T细胞与0.49、1.0mg.mL-1葛根素孵育1h后,以30mJ.cm-2UVB直接照射细胞,24h后收集细胞测定细胞凋亡率和p53蛋白。结果葛根素预处理HaCa T细胞的凋亡率下降,同时细胞表达的p53蛋白减少。结论预防性葛根素抑制UVB诱导的HaCa T细胞凋亡,可能与下调p53蛋白有关。
Objective To investigate the effects of puerarin on UVB-induced HaCa T cell apoptosis. Methods After HaCa T cells were incubated with 0.49 and 1.0 mg.mL-1 puerarin for 1 h, the cells were irradiated with 30 mJ.cm-2 UVB. The apoptosis rate and p53 protein were measured 24h after the cells were harvested. Results Puerarin pretreatment HaCa T cells decreased the apoptosis rate, while cells decreased expression of p53 protein. Conclusion Preventive puerarin can inhibit UVB-induced apoptosis of HaCa T cells, which may be related to the down-regulation of p53 protein.