众所周知,新生期所提呈的抗原即可认为是自身抗原,这样机体就对这些抗原产生了耐受。但人们对T 细胞耐受的发生机制却知之甚微,只是认为,自身蛋白必须与MHC 分子结合后共同表达于胸腺,再由胸腺的抗原提呈细胞将其呈递给抗原特异性T细胞,进而诱导出自身耐受。最近,作者研 It is well-known that the antigens presented in the neonatal period can be considered as self-antigens, thus the body can tolerate these antigens. However, the mechanism of T-cell tolerance is poorly understood. It is only that the self-protein must be expressed in the thymus after binding to the MHC molecule and presented to the antigen-specific T cells by the antigen presenting cells in the thymus Induce self-tolerance. Recently, the author research