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Background: Although left-lobe donation is considered safer, right-sided donor hepatectomy predominatesin adult living donor liver transplantation (LDLT). We hypothesized that bilateral proficiency with donorhepatectomy reduces overall donor complications.Methods: A retrospective review of 834 adult LDLT donors (221 left lobes) from January 2004 toDecember 2014 was performed, dividing cases into two eras based on left-graft experience. Donorcomplications within 6 months were investigated, focusing on graft side and surgical era.Results: The overall complication rate was 17.6％, and was higher in right-lobe donors. In Era 2, duringwhich left-lobe donation rates were three times higher, total complications decreased (14.7％ vs. 20.9％,P=0.02). A significant reduction in postoperative ascites accounted for the lower overall complication rate.The proportion of major biliary complications (BCs) was halved from 62.5％ to 25.0％. Right-lobe donorcomplications also decreased significantly (15.8％ vs. 22.9％, P=0.032), demonstrating that it was not onlyincreased left-lobe donations leading to lowered complication rates, but also greater experience with donorhepatectomy in general.Conclusions: Accumulating experience with bilateral donor hepatectomy leads to decreased donormorbidity and comparable outcomes for right and left lobes, further enhancing the goal of donor safety whilebalancing recipient needs.