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目的:扁桃体是淋巴结外恶性淋巴瘤的好发部位,本研究对扁桃体恶性淋巴瘤的临床特点和预后因素进行分析,探讨临床指标与预后的关系。方法:对我院1990年1月至2000年12月收治的26例原发于扁桃体的恶性淋巴瘤患者的临床特点,预后因素、治疗进行总结,并结合文献进行分析。结果:本组扁桃体恶性淋巴瘤患者以中老年居多,病理均为非霍奇金淋巴瘤(non-hodgkin’slymphoma,NHL)。中高度恶性居多。全组5年总生存率、癌症相关生存率、无瘤生存率分别为68%、70.8%、61%。死亡15例,12例死于肿瘤本身,3例死于并发症。Cox多因素分析显示,年龄、国际预后指数(internationalprognosticIndex,IPI)、血清乳酸脱氢酶(serumlactatedehydrogenase,LDH)、一般状况和分期是影响预后的独立因素。结论:原发于扁桃体的非霍奇金淋巴瘤,年龄、IPI、LDH、一般状况和分期是预后的重要指标。早期发现,早期治疗是提高生存率的重要途径。
OBJECTIVE: Tonsils are the predilection site of malignant lymphoma outside the lymph nodes. This study analyzed the clinical features and prognostic factors of tonsil malignant lymphomas and explored the relationship between clinical indicators and prognosis. METHODS: The clinical features, prognostic factors, and treatment of 26 patients with primary malignant tonsil lymphoma treated in our hospital from January 1990 to December 2000 were summarized and analyzed. Results: The patients with tonsil malignant lymphoma were mostly middle-aged and old, and the pathology was non-hodgkin’s lymphoma (NHL). Mostly highly vicious. The overall 5-year overall survival rate, cancer-related survival rate, and disease-free survival rate were 68%, 70.8%, and 61%, respectively. Of the 15 deaths, 12 died of tumor itself and 3 died of complications. Cox multivariate analysis showed that age, international prognostic index (IPI), serum lactate dehydrogenase (LDH), general condition and staging were independent factors affecting prognosis. CONCLUSIONS: Age, IPI, LDH, general condition, and staging are important prognostic indicators in non-Hodgkin’s lymphoma of the tonsils. Early detection, early treatment is an important way to improve survival.