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目的探讨Ｃ肽（ＣＰ）和胰岛素样生长因子Ⅰ（ＩＧＦＩ）水平在小于胎龄（ＳＧＡ）儿的变化及其意义。方法利用放射免疫分析法测定了４８例ＳＧＡ儿脐血清和其中的３７例ＳＧＡ儿生后一周内外周血ＣＰ和ＩＧＦⅠ。结果ＳＧＡ儿脐血ＣＰ和ＩＧＦＩ水平低于适于胎龄（ＡＧＡ）儿水平，且ＳＧＡ儿的不良生长程度越重，ＣＰ和ＩＧＦⅠ水平越低，生后一周内，重度ＳＧＡ儿外周血ＣＰ和ＩＧＦⅠ仍维持低水平，而轻度ＳＧＡ儿ＣＰ和ＩＧＦⅠ则上升至ＡＧＡ儿水平。结论ＳＧＡ儿的不良生长与低胰岛素和ＩＧＦⅠ水平有关。
Objective To investigate the changes of C-peptide (CP) and insulin-like growth factor Ⅰ (IGF-I) in infants with gestational age (SGA) and its significance. Methods Radioimmunoassay was used to determine the serum levels of CP and IGF-Ⅰ in 48 SGA cord blood and 37 SGA children within one week after their birth. Results The levels of CP and IGFI in cord blood of SGA children were lower than that of AGA children, and the worse the growth of SGA children was, the lower the level of CP and IGFⅠ. One week after birth, severe SGA Peripheral blood CP and IGF Ⅰ still maintain a low level, while mild SGA children CP and IGF Ⅰ increased to AGA level. Conclusion SGA children with poor growth and low insulin and IGF Ⅰ level.