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目的:探究门冬胰岛素注射液联合维生素D治疗妊娠期糖尿病(GDM)的效果及对血清糖化血红蛋白(HbA1c)、视黄醇结合蛋白4(RBP4)、脂联素(APN)水平的影响。方法:抽取2016年6月至2020年6月在驻马店市中心医院接受治疗的GDM患者84例，采用随机数字表法分为观察组和对照组，每组42例。观察组采用门冬胰岛素注射液联合维生素D治疗，对照组仅采用门冬胰岛素注射液治疗。检测并比较两组患者治疗前后胰岛素抵抗相关因子[RBP4、HbA1c、APN及脂肪素(VF)]浓度、血糖代谢相关因子[空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)]以及钙磷水平变化情况，并记录两组母婴结局。结果:治疗后，观察组RBP4、HbA1c、VF、FBG、FINS、HOMA-IR均低于对照组(n P均<0.05)，APN、血钙、钙磷乘积均高于对照组(n P均0.05)。观察组不良结局总发生率(7.14%，3/42)低于对照组(26.19%，11/42)，n P<0.05。n 结论:门冬胰岛素注射液联合维生素D可显著改善GDM患者的胰岛素抵抗情况，维持其血糖和钙磷平衡，降低母婴不良妊娠结局发生率。“,”Objective:To investigate the curative effect of insulin aspart injection combined with vitamin D on patients with gestational diabetes mellitus (GDM), and its influences on levels of serum glycosylated hemoglobin (HbA1c), retinol binding protein 4 (RBP4) and adiponectin (APN).Methods:A total of 84 GDM patients treated in Zhumadian Central Hospital from June 2016 to June 2020 were enrolled and divided into observation group and control group by random number table method, with 42 cases in each group. The observation group was treated with insulin aspart injection and vitamin D, while control group was only treated with insulin aspart injection. The changes in levels of insulin resistance-related factors, such as RBP4, HbA1c, APN, visfatin (VF), blood glucose metabolism-related factors, such as fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance index (HOMA-IR), and calcium-phosphorus before and after treatment were detected and compared between the two groups. The maternal and neonatal outcomes in both groups were observed and recorded.Results:After treatment, RBP4, HbA1c, VF, FBG, FINS and HOMA-IR in observation group were lower than those in control group (n P<0.05); while APN, blood calcium and calcium-phosphorus product were higher than those in control group (n P0.05). The total incidence of adverse outcomes in observation group (7.14%, 3/42) was lower than that in control group (26.19%, 11/42),n P<0.05.n Conclusions:Insulin aspart injection combined with vitamin D can significantly improve the insulin resistance of GDM patients, maintain the balance of blood glucose and calcium-phosphorus, and reduce the incidence of poor maternal and neonatal outcomes.