论文部分内容阅读
目的 N-乙酰天门冬氨酸(NAA)定量研究对新生儿核黄疸的评价及诊断。方法 10例新生儿核黄疸和8例年龄匹配的健康足月儿纳入我们的研究,波谱采用采用德国西门子Sonata1.5T超导型核磁共振仪,多体素氢质子波谱脑检查,点分辨波谱(PRESS)序列,TR 1 500ms,TE 135ms,兴趣区为两侧基底节区。结果 10个新生儿核黄疸,7个在T1加权像可见苍白球对称性高信号,T2加权像可见苍白球呈等信号。新生儿核黄疸组基底节区NAA和NAA/Cr较对照组相比明显降低,两组差别有统计学意义(P﹤0.05)。新生儿核黄疸组基底节区CHO/NAA较对照组相比明显升高,两组差别有统计学意义(P﹤0.05)。新生儿核黄疸组基底节区NAA值分布范围,只有一例与对照组有交叉重叠,其余没有交叉重叠。结论氢质子波谱及常规MRI对于新生儿核黄疸的评价及诊断有一定的意义,NAA定量研究对新生儿核黄疸的评价也有一定的价值。
Objective To evaluate the value of N-acetyl-aspartate (NAA) quantitative determination of neonatal kernicterus and its diagnosis. Methods Ten cases of neonatal kernicterus and 8 age-matched healthy full-term infants were enrolled in our study. The spectra were analyzed by Sonata 1.5T superconducting magnetic resonance spectroscopy, multi-voxel proton magnetic resonance spectroscopy, point-resolved spectroscopy PRESS) sequence, TR 1 500ms, TE 135ms, the region of interest is the bilateral basal ganglia. Results 10 neonates with kernicterus, 7 hyperintensities of globus pallidus were observed in T1 weighted images and pale globules were observed in T2 weighted images. Neonatal kytoplasm NAA and NAA / Cr in the basal ganglia were significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05). Compared with the control group, neonatal kernicterus cholecystokinin CHO / NAA significantly increased, the difference between the two groups was statistically significant (P <0.05). Neonatal kytoplasm NAA value distribution range, only one case of cross-overlap with the control group, the rest did not overlap. Conclusions Hydrogen proton spectroscopy and conventional MRI have certain significance for the evaluation and diagnosis of neonatal kernicterus. Quantitative study of NAA is also of value in the evaluation of neonatal kernicterus.