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妊娠中期羊膜穿刺术和绒毛取样（CVS）是获得胎儿遗传信息的成熟技术。羊膜穿刺术被认为是产前诊断遗传性疾病侵入性检查的金标准，1952年用于鉴定产前溶血性疾病，
Mid-pregnancy amniocentesis and villus sampling (CVS) are mature techniques for obtaining fetal genetic information. Amniocentesis is considered the gold standard for prenatal diagnosis of invasive genetic diseases, 1952 for the identification of prenatal hemolytic disease,