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目的：探讨米索前列醇用于晚期妊娠引产的安全性及效果。方法：对９０ 例妊娠３３ ～４３ 周有引产指征的初产妇，随机分成两组，米索前列醇组（４６ 例） 、对照组（４４ 例） ， 分别用米索前列醇５０ μｇ 阴道后穹窿用药引产及用催产素引产。结果：米索前列醇组晚期妊娠引产的有效率为９５ ．６５ ％ ，显著高于对照组的８１ ．８２ ％ （ Ｐ＜ ０ ．０５） ， 两组宫颈评分提高程度比较差异有非常显著性意义（ Ｐ＜ ０ ．０１） 。米索前列醇组引产时间、总产程显著短于对照组（ Ｐ ＜ ０ ．０５） 。两组新生儿情况比较无显著性差异（ Ｐ ＞ ０ ．０５） 。结论：阴道后穹窿放置米索前列醇用于晚期妊娠引产能促宫颈成熟及发动子宫收缩，是一种方便、有效、较安全的引产方法。
Objective: To investigate the safety and efficacy of misoprostol in induction of labor during late pregnancy. Methods: A total of 90 primiparae women with induction of labor during the 33-43 weeks of gestation were randomly divided into two groups: misoprostol group (n = 46) and control group (n = 44) Fornix medication induced abortion and oxytocin induction. Results: Misoprostol late pregnancy induction of labor was 95%. 65%, significantly higher than the control group 81. 82% (P <0.05). There was significant difference between the two groups in the improvement of cervical score (P <0.01). Misoprostol group induction of labor time, total production was significantly shorter than the control group (P <0 .05). No significant difference between the two groups of newborns (P> 0.05). Conclusion: Misoprostol placed in the posterior vaginal fornix can induce cervical ripening and uterine contractions in late pregnancy, which is a convenient, effective and safe method of induction of labor.