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目的观察血管紧张素受体拮抗剂替米沙坦联合安体舒通应用于老年心衰的治疗效果。方法选取我院2011年1月~2013年1月间我院收治的90例老年心力衰竭患者,将其随机分为观察组与对照组,每组45例,两组均给予强心、扩血管药物治疗,在此基础上观察组联合应用替米沙坦40mg,每天1次以及安体舒通40mg,每天1次治疗,对照组仅采用安体舒通40mg,每天1次治疗,比较两组患者治疗前后的心功能变化情况。结果治疗后NYHA、BNP、LVEDD、LVESD水平均较治疗前明显改善,且观察组改善情况更明显,组间比较差异有统计学意义,P<0.05。治疗后两组心率、收缩压、舒张压水平比较无明显差异,P>0.05。结论安体舒通与替米沙坦合用于治疗老年心衰可以显著改善患者的心功能,提高治疗效果,值得推广应用。
Objective To observe the therapeutic effect of angiotensin receptor antagonist telmisartan combined with spironolactone on senile heart failure. Methods 90 elderly patients with heart failure admitted to our hospital from January 2011 to January 2013 were randomly divided into observation group and control group, with 45 cases in each group. Both groups were given cardiotomy, vasodilator Drug treatment, on the basis of the observation group combined telmisartan 40mg, once a day and spironolactone 40mg, once a day treatment, the control group only with spironolactone 40mg, 1 day treatment, the two groups were compared Patient before and after treatment of cardiac function changes. Results After treatment, the levels of NYHA, BNP, LVEDD and LVESD were significantly improved compared with that before treatment, and the improvement in the observation group was more obvious. There was significant difference between the two groups (P <0.05). After treatment, heart rate, systolic blood pressure and diastolic blood pressure in the two groups showed no significant difference (P> 0.05). Conclusion The combination of spironolactone and telmisartan in the treatment of elderly patients with heart failure can significantly improve cardiac function and improve the therapeutic effect, which is worth popularizing and applying.