论文部分内容阅读
氟比洛芬是布洛芬类非甾体抗炎药物（NSIDs），临床上用于急性或长期类凤湿性关节炎与骨关节炎的治疗，但口服给药对胃肠道有刺激性，且代谢迅速，局部药物浓度低，为了提高局部药物浓度，延长作用时间，探求缓释微球关节腔给药的可行性，我们选用药用A型明胶为材料，氟比洛芬为模型药物制备了粒径大小符合关节腔注射要求的氟比洛芬明胶微球，粒径分布集中在2．5－12．3μm范围内，药物的包封率为5．02％，氟比洛芬明胶微球体外释药缓慢，t70＝12h，符合Higuchi释药规律。
Flurbiprofen is an ibuprofen non-steroidal anti-inflammatory drug (NSIDs), clinically used for the treatment of acute or chronic rheumatoid arthritis and osteoarthritis, but oral administration of gastrointestinal irritation, In order to improve the local drug concentration, prolong the action time and explore the feasibility of sustained-release microsphere joint cavity administration, we choose medicinal A-type gelatin as material and flurbiprofen as model drug The particle size distribution of flurbiprofen gelatin microspheres with particle size matching the requirements of the articular cavity injection was concentrated in the range of 2.5-12.3μm, the entrapment efficiency of the drug was 5.02%, the content of flurbiprofen gelatin In vitro release slow ball, t70 = 12h, consistent with Higuchi release rules.