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目的:优选中药复方制剂艾可清胶囊的提取工艺。方法:以淫羊藿苷、虎杖苷、甘草酸、黄芩苷的提取率为指标,采用正交试验设计筛选提取工艺条件,结合综合评分优选最佳工艺条件。结果:优选出的提取条件为30倍量65%乙醇加热回流提取淫羊藿2次,每次3 h,提取液减压浓缩至相对密度为1.10(60℃);3倍量20%乙醇室温放置8 h去除叶绿素;10倍量80%乙醇提取虎杖、黄芩、甘草等混合药材粗粉3次,每次2 h。结论:经中试验证,指标成分提取率为66%～88%,表明优选工艺可行。
Objective: To optimize the extraction process of traditional Chinese medicine Aiqin capsule. Methods: Icariin, polydatin, glycyrrhizin, baicalin extraction rate as an indicator, using orthogonal experimental design screening process conditions, combined with the comprehensive evaluation of the best optimization of process conditions. Results: The extraction conditions were as follows: 30 times the amount of 65% ethanol refluxed Epimedium 2 times, each 3 h, the extract was concentrated under reduced pressure to a relative density of 1.10 (60 ℃); 3 times the amount of 20% ethanol at room temperature Placed 8 h to remove chlorophyll; 10 times the amount of 80% ethanol extraction Polygonum cuspidatum, Scutellaria, licorice and other mixed herbs meal 3 times, each 2 h. Conclusion: Through the pilot test, the extraction rate of the indicator components is 66% ~ 88%, indicating that the preferred process is feasible.