局部使用二性霉素B的一个问题是不耐受,因此对治疗的反应不好。对0.3％或较大浓度制剂的不耐受是由于脱氧胆酸钠对眼的刺激;加此为使二性霉素B能溶于水。0.15％浓度的二性霉素B是可耐受并对角膜真菌病治疗有效。作者报告12例角膜真菌病病人,其中8人自溃疡有阳性刮片和培养出真菌。2例病人刮片阳性而培养阴性。2例培养和涂片阴性病人,根据临床表现做出诊断。每一病人均按相似方法治疗。在最初48～72小时内,局部滴用0.15％二性霉素B,每1/2～1小时一次。用阿托品散瞳。在48～72小时内主觉 One of the problems with topical amphotericin B is intolerance and therefore poor response to treatment. Intolerance to 0.3% or greater concentrations is due to eye irritation of sodium deoxycholate; this is added to render amphotericin B water soluble. Amphotericin B at a concentration of 0.15% is tolerated and effective in the treatment of corneal mycosis. The authors reported 12 patients with corneal mycosis, of whom 8 had positive smear and developed fungi from ulcers. Two patients had positive smears and negative cultures. 2 cases of culture and smear-negative patients, make a diagnosis based on clinical manifestations. Each patient is treated in a similar way. In the first 48 to 72 hours, local drip 0.15% amphotericin B, once every 1/2 ~ 1 hour. Mydriasis with atropine. In 48 to 72 hours main fact