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B淋巴细胞受抗原刺激后,可行分裂增殖,分化成为浆母细胞,进一步成熟为浆细胞。浆细胞即为抗体生成细胞,它能分泌免疫球蛋白(Immunoglobulin,Ig),并释入血液,使机体产生对相应抗原的体液免疫。 B淋巴细胞功能的缺陷或降低,表现为体内Ig量的下降,特异性抗体缺乏,细胞对抗原或有丝分裂素的应答反应减弱,体内抗体生成细胞数量减少等。相反的,如果B淋巴细胞功能异常,可在血液中发现增多的产生抗体的肿瘤浆细胞及异常增高的某一类Ig。抗体和Ig是同义词,但并不是所有的Ig都具有抗体活性,例如多发性骨髓瘤,由肿瘤细胞所产生的Ig至今尚未发现它具有抗体活性。
B lymphocytes stimulated by antigen, feasible proliferation, differentiation into plasma cells, and further mature into plasma cells. Plasma cells are antibody-producing cells that secrete Immunoglobulin (Ig) and release it into the bloodstream to allow the body to produce humoral immunity to the corresponding antigen. Defects or decreases in B-lymphocyte function are manifested by a decrease in Ig in vivo, a lack of specific antibodies, a diminished response of cells to antigens or mitogens, and a decrease in the number of antibody-producing cells in vivo. Conversely, if B lymphocytes function abnormally, an increased number of antibody-producing tumor plasma cells and an abnormally high class of Ig may be found in the blood. Antibodies and Ig are synonymous, but not all Ig have antibody activity, such as multiple myeloma, and Igs produced by tumor cells have so far not been found to have antibody activity.