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研究更准确、直接的预测肺动脉压力(PAP)的LS法肺灌注显象。将10条犬随机分为前列腺素F2a组和多巴胺组,分别于用药前、后共3个PAP水平,于呼气末静脉注射99mTc—MAA行侧卧位肺灌注显象。结果:右侧卧位时左侧肺边部局部相对单位灌注血流量F与对应的该点与双肺几何中心点的距离h适合于公式F=B(PAP-hD)2,其中F=局部平均单位血流量Qr/双肺平均单位血流Qm,B是常数,与Qm呈反比,D是血液比重=1.06,利用该公式作LeastSquare回归,可计算出PAP;计算出的PAP与测出的PAP呈正相关(γ=0.96,P=0.0001),与PCWP呈负相关(γ=-0.82,P<0.01)。结论:应用该方法计算出的PAP比报道的LR法计算的左侧卧位至右侧卧位血流转移值与测出的PAP有更好的相关,而且本研究中所计算出的是肺动脉压力值;本方法能更准确和直接地预测PAP。
To study more accurate and direct pulmonary artery pressure (PAP) prediction of pulmonary perfusion imaging. Ten dogs were randomly divided into two groups: prostaglandin F2a group and dopamine group. Three PAP levels before and after endoscopic perfusion imaging were performed in 99mTc-MAA group. Results: The relative perfusion flow F at the left lung border and the corresponding distance h between this point and the geometric center of the double lung at the right lateral position were suitable for the formula F = B (PAP-hD) 2, where F = local Average unit blood flow Qr / average lung unit blood flow Qm, B is constant, inversely proportional to Qm, D is the blood specific gravity = 1.06, using this formula for LeastSquare regression, can calculate the PAP; PAP calculated and measured PAP (r = 0.96, P = 0.0001), negatively correlated with PCWP (r = -0.82, P <0.01). CONCLUSIONS: PAP calculated using this method is better correlated with measured PAP than the reported LR-LVD to right-lateral decubitus, and the calculated pulmonary artery Pressure value; this method can predict PAP more accurately and directly.