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流行病学显示呼吸道合胞病毒(RSV)诱发或加重支气管哮喘(哮喘)。许多研究从免疫学、病理生理学角度推测两者之间联系的机制。单纯RSV感染气道反应性轻度增高且呈一过性,嗜酸粒细胞肺浸润不明显,辅助性T细胞中TH1细胞克隆被激活,CD4+特别是CD8+亚群的IFN-γ增高。哮喘是以嗜酸粒细胞浸润为特征的慢性炎症,其气道反应性明显增高,T细胞中TH2被激活,IL-4、IL-5增高明显。本文主要从气道反应性、嗜酸粒细胞、T细胞亚群的改变来探付RSV与哮喘的关系。
Epidemiology shows that respiratory syncytial virus (RSV) induces or aggravates bronchial asthma (asthma). Many studies have speculated from the immunology, pathophysiology, the mechanism of the connection between the two. In mild RSV infection, the airway reactivity was slightly increased and transient, with infiltrating eosinophils infiltrated. TH1 cell clones in helper T cells were activated and IFN-γ in CD4 + CD8 + subsets was increased. Asthma is characterized by eosinophilic infiltration of chronic inflammation, airway reactivity was significantly increased, T cells were activated T cells, IL-4, IL-5 increased significantly. This article mainly from the airway reactivity, eosinophils, T cell subsets changes to explore the relationship between RSV and asthma.