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副肾皮质激素类药物,若在α,β不饱和酮A环中引入1-C及2-C间的双键,往往可以增加疗效.如△~1氢化可的松较氢化可的松的活性强3～5倍,引进1-C和2-C间的双键,虽已有SeO_2、DDQ、脱HX、微生物等方法,但均有缺点,故仍需寻找新的方法.近年来Barbon等报道用苯亚硒酐对甾体A环能进行1-C和2-C位的脱氢;也能氧化羟基.而17-C位具有α-叔羟酮边链的甾酮其1-C,2-C位的脱氢则未见报道.鉴于副肾皮质激素类
Adrenocortical hormone drugs, if the α, β unsaturated ketone A ring into the 1-C and 2-C double bond, often can increase the curative effect, such as △ ~ 1 hydrocortisone hydrocortisone than hydrocortisone Strong activity of 3 to 5 times, the introduction of double bonds between 1-C and 2-C, although there SeO_2, DDQ, HX, microorganisms and other methods, but both disadvantages, so still need to find new ways. In recent years Barbon Et al. Reported that benzeneselenide anhydride can steroid A ring can be carried out at the 1-C and 2-C position dehydrogenation; also hydroxyl. And 17-C-position α-tert-hydroxy ketone side chain steroid 1- C, 2-C position dehydrogenation has not been reported. In view of the adrenal cortex hormones