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[目的]评价含顺铂的联合方案NP与MVP对复治的晚期非小细胞肺癌的近期疗效。[方法]106例晚期非小细胞肺癌随机被分为两组。NP组48例 ,其中Ⅲb期12例 ,Ⅳ期36例 ,鳞癌12例 ,腺癌30例 ,鳞腺混合型6例 ,采用诺维本25mg/m2 静脉推注 ,第1,8天 ;顺铂90mg/m2 静脉滴注 ,第1天 (配合水化 )。MVP组58例 ,其中Ⅲb期8例 ,Ⅳ期50例 ,鳞癌14例 ,腺癌36例 ,鳞腺混合型8例 ,采用丝裂霉素6mg/m2 静脉推注 ,第1天 ;VDS3mg/m2 静脉推注 ,第1,8天 ;顺铂90mg/m2 ,静脉滴注 ,第1天 (配合水化 )。两方案均为每3周为1周期 ,治疗2周期后评价疗效与毒副反应。[结果]NP组有效率(RR)为37.5% ,MVP组RR为31.0% ,差异无显著性 (P>0.05)。腺癌疗效比鳞癌稍好 ,主要毒副反应为骨髓抑制、消化道反应、周围神经毒性及静脉炎。目前均能采取相应的防治措施。[结论]NP与MVP方案均为治疗非小细胞肺癌的第一线治疗方案 ,也适用于复治的晚期非小细胞肺癌 ,更适用于基层医院的治疗
[Objective] To evaluate the short-term curative effect of cisplatin-containing combination NP and MVP on retreatment advanced non-small cell lung cancer. [Method] 106 cases of advanced non-small cell lung cancer were randomly divided into two groups. There were 48 cases in NP group, including 12 cases of stage Ⅲb, 36 cases of stage Ⅳ, 12 cases of squamous cell carcinoma, 30 cases of adenocarcinoma and 6 cases of mixed squamous gland. Cisplatin 90mg / m2 intravenous infusion, the first day (with hydration). Fifty-eight patients in MVP group, including 8 cases in stage Ⅲb, 50 cases in stage Ⅳ, 14 cases of squamous cell carcinoma, 36 cases of adenocarcinoma and 8 cases of mixed adenocarcinoma, were treated with mitomycin 6 mg / m 2 intravenously on day 1; VDS 3 mg / m2 intravenous injection, day 1,8; cisplatin 90mg / m2, intravenous infusion, the first day (with hydration). The two programs are every 3 weeks for a period of 2 weeks after the treatment evaluation of efficacy and toxicity. [Results] The effective rate (RR) of NP group was 37.5%, and the RR of MVP group was 31.0%, with no significant difference (P> 0.05). The efficacy of adenocarcinoma slightly better than squamous cell carcinoma, the main side effects of myelosuppression, gastrointestinal reactions, peripheral neurotoxicity and phlebitis. At present can take the appropriate prevention and treatment measures. [Conclusion] Both NP and MVP regimens are the first-line treatment for non-small cell lung cancer and are also suitable for advanced non-small cell lung cancer for retreatment. They are more suitable for the treatment of primary hospital