Probes are the interface between microsystems and bio-cells.The ideal interface is one-to-one interface.Though variousresearch groups have been able to establish some sort of interfaces after many years of research,they are very crude.Neurons aremillions in numbers,whereas the prostheses successfully built so far have only a few hundred probes at best.Creating an ef-fective interface is still far away.Though we have micro-and nano-technologies,we couldn’t build a prosthesis with an effectiveresolution.Main reasons behind it are the type of probe being used and the poor design of the probe.To address this problem,wedeveloped a methodology to design a probe and an array of probes with better resolution and less resistive donut probe.Thismethodology helps us to design a probe optimizing all the parameters.We presented our methodology through a design that iscapable of 70 μm penetration inside the tissue.The tissue heating by our designed probe is only 0.411 °C.We also characterizedthe donut probe,which could be used by any research group to design a donut probe of their specific need. Probes are the interface between microsystems and bio-cells. The ideal interface is one-to-one interface.Though various research groups have been able to establish some sort of interfaces after many years of research, they are very crude. Neurons aremillions in numbers, while the prostheses successfully built so far have only a few hundred probes at best.Creating an ef-fective interface is still far away.Though we have micro-and nano-technologies, we could not build a prosthesis with an effective solution .Main reasons behind it are the type of probe being used and the poor design of the probe. To address this problem, wedeveloped a methodology to design a probe and an array of probes with better resolution and less resistive donut probe. Thismethodology helps us to design a probe optimizing all the parameters.We presented our methodology through a design that iscapable of 70 μm penetration inside the tissue. tissue heating by our designed probe is only 0.411 ° C .We also characterizedthe d onut probe, which could be used by any research group to design a donut probe of their specific need.