受 HIV感染者常同时有结核杆菌的感染 ,从而需要同时对这两种病原微生物进行治疗。当今治疗结核菌的主要药物是利福平 ,而在 HIV感染者中它只限于与核苷逆转录酶抑制剂类药物伍用 ,齐多夫定为其中的一种。本研究的目的为明确多次服用利福平对于齐多夫定的稳态药代动力学及其 5 People living with HIV often have Mycobacterium tuberculosis infection at the same time, which requires the simultaneous treatment of both pathogenic microorganisms. Currently, the main drug used to treat TB is rifampicin, which is only limited to use with nucleoside reverse transcriptase inhibitors in HIV-infected patients. Zidovudine is one of them. The purpose of this study was to determine the steady-state pharmacokinetics of zidovudine taken repeatedly with rifampicin and its 5