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目的探讨米索前列醇联合米非司酮用于中期妊娠引产的效果。方法随机选取2012年2月至2015年2月自愿终止妊娠且无引产禁忌证孕中期患者130例,分为对照组和观察组,每组65例,对照组孕妇给予羊膜腔内注射利凡诺引产,观察组孕妇则采取米索前列醇联合米非司酮引产,比较两组孕妇的产程时间、宫缩发作时间、产后出血量及引产效果。结果观察组孕妇产程时间、宫缩发作、产后出血量均小于对照组,差异有统计学意义(P<0.05)。观察组孕妇完全引产率(92.31%)高于对照组(78.46%),差异有统计学意义(χ2=4.9929,P<0.05)。结论米索前列醇联合米非司酮用于中期妊娠引产可有效缩短孕妇的产程时间和宫缩发作时间,减少产后出血量,值得在临床上推广应用。
Objective To investigate the effect of misoprostol combined with mifepristone on induction of labor during mid-term pregnancy. Methods A total of 130 pregnant women with voluntary termination of pregnancy and no contraindications to induction of labor during the period from February 2012 to February 2015 were randomly divided into control group and observation group with 65 cases in each group.The control group received amniotic injection of rivanolol Induction, observation group pregnant women were taken misoprostol combined with mifepristone induction of labor, the two groups of pregnant women during labor, contractions time, postpartum hemorrhage and induction of labor. Results The duration of labor, uterine contractions and postpartum hemorrhage in the observation group were all less than those in the control group (P <0.05). The total induction rate of pregnant women in the observation group (92.31%) was higher than that of the control group (78.46%), the difference was statistically significant (χ2 = 4.9929, P <0.05). Conclusion Misoprostol combined with mifepristone for induction of labor during the second trimester of pregnancy can effectively shorten the delivery time of pregnant women and the time of contractions and reduce the amount of postpartum hemorrhage, which is worth popularizing in clinic.