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Poor differentiation is an important hallnnark of cancer cells,and differentiation therapy holds great promise for cancer treatment.The restoration of IkB kinase a(IKKa)leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity.The findings by Yan et al.validate the polycomb protein enhancer of zeste homologue2(EZH2)as a target for intervention.
Poor differentiation is an important hallnnark of cancer cells, and differentiation therapy holds great promise for cancer treatment. The restoration of IkB kinase a (IKKa) leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity. The findings by Yan et al. Validate the polycomb protein enhancer of zeste homologue2 (EZH2) as a target for intervention.