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为探讨P16基因在子宫内膜癌发生及发展过程中所起的作用，采用免疫组化SP法对38例子宫内膜癌（腺癌33例，腺棘皮癌4例，浆液性乳头状腺癌1例)及19例正常组织进行了p16蛋白的免疫组化检测，结果p16蛋白在正常组织中表达率为56.8％，在腺癌中的表达率为21.7％，在腺棘皮和浆液性乳头腺癌中的表达率为25.1％，与正常组差异显著，同时，p16蛋白在I～II期子宫内膜中的表达率为26.4％。而在III～IV期子宫内膜癌中的表达率为11.7％，二者差异显著，说明p16蛋白在子宫内膜癌的发生及进展过程中起重要作用。
To investigate the role of P16 gene in the occurrence and development of endometrial carcinoma, 38 cases of endometrial carcinoma (adenocarcinoma, adenocarinoma, 4 cases, serous papillary adenocarcinoma) were studied by immunohistochemical SP method. One case) and 19 normal tissues were examined for the p16 protein by immunohistochemistry. The results showed that the expression rate of p16 protein was 56.8% in normal tissue and 21.7% in adenocarcinoma, and it was in the adenotrophic and serous papillary glands. The expression rate in cancer was 25.1%, which was significantly different from that in the normal group. At the same time, the expression rate of p16 protein in the endometrium of stage I-II was 26.4%. The expression rate in stage III-IV endometrial carcinoma was 11.7%. There was significant difference between the two, indicating that p16 protein plays an important role in the occurrence and progression of endometrial carcinoma.