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率达９０．７％ 。不良反应（表６）如下所列，其中有一例因剧烈呕吐而中止用药。讨 论美施康定（Ｍｏｒｐｈｉｎｅ Ｓｕｌｐｈａｔｅ ＣｏｎｔｒｏｌｌｅｄｒｅｌｅａｓｅＴａｂｌｅｔｓ，ＭＳｃｏｎｔｉｎ）为新研制的硫酸吗啡控释片。由于其镇痛时间长，使用方便，作为口服已被病人所接受，但对于那些伴有顽固性恶心或吞咽困难的晚期消化道肿瘤病人，其癌性疼痛常不能通过口服给药来解决。我院用直肠给药方式，给药间隔基本不变，其疼痛缓解率达９０．７％ ，与文献报道口服给药的有效率９０～９３％ 相似，且使用方便，可避免肌肉、静脉、皮下和鞘内方式给病人带来痛苦，便于门诊和家庭使用。就不良反应而言，本组有便秘、恶心、呕吐、嗜睡和幻觉，但都能通过对症处理加以解决，且没有任何明显的局部付反应，仅一例因剧烈的呕吐导致用药失败，分析原因，此患者有不完全性的肠梗阻，因此，治疗前详细的病史询问和体格检查是防止用药失败的一个基本保证。总之，美施康定直肠给药治疗有顽固性恶心或吞咽困难的晚期消化道肿瘤病人癌性疼痛是一种安全、有效、简单的控制癌痛的方式，用直肠给药代替口服给药同样可以获得满意的镇痛效果。
The rate reached 90.7%. Adverse reactions (Table 6) are listed below. One case was discontinued due to severe vomiting. Discusses Morphine Sulphate Controlled-release Tablets (MScontin) as a newly developed morphine sulfate controlled-release tablet. Because of its long duration of analgesia and ease of use, it has been accepted by the patient as oral, but for patients with advanced gastrointestinal cancers with refractory nausea or dysphagia, the cancerous pain is often not resolved by oral administration. With rectal administration in our hospital, the interval of administration is basically unchanged, and the pain relief rate reaches 90.7%. It is similar to the reported oral administration efficiency of 90 to 93%, and it is easy to use and can avoid muscles, veins, The subcutaneous and intrathecal methods bring suffering to the patient and are convenient for out-patient and family use. In terms of adverse reactions, this group has constipation, nausea, vomiting, drowsiness and hallucinations, but all can be resolved through symptomatic treatment, and there is no obvious local reaction, only one case of drug failure due to severe vomiting, analysis of the reasons, This patient has incomplete intestinal obstruction, so detailed medical history and physical examination before treatment is a basic guarantee against drug failure. In conclusion, Methinkardine rectal administration for cancer patients with advanced nausea or dysphagia in advanced gastrointestinal cancer is a safe, effective and simple way to control cancer pain. It is also possible to use rectal administration instead of oral administration. Get satisfactory pain relief.