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目的 :探讨 p5 3蛋白在子宫颈癌组织中表达的临床意义。方法 :用鼠抗人 p5 3单克隆抗体 ,以 SP免疫组化法检测 p5 3蛋白。结果 :p5 3蛋白阳性表达率为 5 6 .3 % ,其表达与肿瘤大小、TNM分期、有无淋巴结转移无关 (P>0 .0 5 ) ,与肿瘤分化程度有关 (P<0 .0 1)。 p5 3蛋白阳性与阴性组比较 ,其术后生存率差异有显著性 (P<0 .0 1)。结论 :子宫颈癌组织中 p5 3蛋白表达与肿瘤大小、TNM分期及有无淋巴结转移无关 ,与肿瘤分化程度密切相关 ,并可用于判断预后。
Objective: To investigate the clinical significance of p5 3 protein in cervical cancer. Methods: The p5 3 protein was detected by SP immunohistochemistry with mouse anti-human p5 3 monoclonal antibody. Results: The positive expression rate of p5 3 protein was 53.3%. The expression of p5 3 protein was not related to tumor size, TNM stage and lymph node metastasis (P> 0.05), and was correlated with tumor differentiation (P <0.01) ). There was a significant difference in postoperative survival between p5-3 protein positive and negative groups (P <0.01). Conclusion: The expression of p5 3 protein in cervical cancer is not related with the tumor size, TNM stage and lymph node metastasis. It is closely related to the degree of tumor differentiation and can be used to judge the prognosis.