本文报告铜蓝蛋白(Ceruloplasmin简称Cp)对体外培养的2BS成纤维细胞蛋白质的合成有促进作用,在Cp(300微克/毫升)作用下,参入2BS细胞的~3H脯氨酸的CPM值增加24.96％。采用间接免疫荧光显微技术观察到外加的铜蓝蛋白能进入到胞浆中。在细胞间隙,Cp呈网络状分布,似粘着于细胞间质的胶原等纤维蛋白之上,提示Cp与胶原等纤维蛋白的形成有一定的联系。 This paper reports that ceruloplasmin (Cp) promotes the synthesis of 2BS fibroblasts cultured in vitro. The CPM value of ~ 3H proline incorporated into 2BS cells increased by 24.96 at Cp (300 μg / mL) %. Indirect immunofluorescence microscopy was used to observe that added ceruloplasmin could enter the cytoplasm. In the intercellular space, Cp was distributed in a network, which seemed to adhere to the fibrin such as collagen in the interstitial of cells, suggesting a certain relationship between Cp and fibrin formation such as collagen.