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用放射免疫双抗体法测定74例哮喘息儿的4种血清内分泌激素水平，并与32名健康儿童比较。结果哮喘患儿的血清皮质醇（314．27±207．90nmol／L）、促甲状腺素（1．89±1．26mIU／L）水平均显著低于健康儿（P均＜0．01），生长激素（3．23±2．34μg／L）略降低（P＞0．05），雌二醇（0．231±0.118nmol／L）则显著高于健康儿，表明哮喘患儿存在内分泌功能紊乱。这可能与长期大剂量应用全身性肾上腺皮质激素，导致丘脑-垂体-肾上腺皮质轴的功能受抑有关。
Four serum endocrine hormones were measured by radioimmunoassay in 74 asthmatic children and compared with 32 healthy children. Results The levels of serum cortisol (314.27 ± 207.90nmol / L) and thyrotropin (1.89 ± 1.26mIU / L) in asthmatic children were significantly lower than those in healthy children (all P <0.01) Growth hormone (3.23 ± 2.34μg / L) was slightly lower (P> 0.05) and estradiol (0.231 ± 0.118nmol / L) was significantly higher than healthy children, indicating that there is endocrine function in children with asthma disorder. This may be related to long-term high-dose systemic corticosteroids, resulting in hypothalamic-pituitary-adrenal axis depression.