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目的探讨心肌肥厚患者冠脉血流与左室舒张功能障碍关系。方法采用彩色多普勒超声仪,行经胸超声心动图(TTE)测量40例心肌肥厚患者和20例正常人冠状窦、二尖瓣及肺静脉血流频谱。结果心肌肥厚患者冠状窦直径、前向血流和净前向血流流速积分(VTInet)明显高于正常对照组;冠状窦前向血流和VTInet与左室舒张功能障碍的多项指标存在相关关系;肺静脉舒张末期逆行血流最大流速之间均存在明显正相关。结论冠脉循环血流动力学的改变可能是心肌肥厚患者舒张功能受损的机制之一.
Objective To investigate the relationship between coronary blood flow and left ventricular diastolic dysfunction in patients with cardiac hypertrophy. Methods Color Doppler ultrasound was used to measure coronary flow, mitral valve and pulmonary venous flow in 40 patients with cardiac hypertrophy and 20 normal subjects by transthoracic echocardiography (TTE). Results The coronary sinus diameter, antegrade flow and net forward flow velocity integral (VTInet) were significantly higher in patients with cardiac hypertrophy than those in the normal control group. The anterior coronary blood flow and VTInet were correlated with many indexes of left ventricular diastolic dysfunction Relationship; Pulmonary venous end-diastolic blood flow between the maximum velocity of reversal there is a clear positive correlation. Conclusion Coronary circulation hemodynamics may be one of the mechanisms of impaired diastolic function in patients with cardiac hypertrophy.