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应用抗ｃｅｒｂＢ２癌基因蛋白（Ｐ１８５）的单克隆抗体，采用免疫组化ＡＢＣ方法，对正常胃粘膜、各级胃粘膜异型增生、早期胃癌及进展期胃癌进行研究。结果：在正常胃粘膜腺体颈部偶见Ｐ１８５蛋白的弱阳性表达；在轻、中、重度异型增生病变中Ｐ１８５蛋白的表达率分别为５０％、８３．３％、８５．７％；在早期及进展期胃癌中Ｐ１８５蛋白的表达率分别为２２．２％和５６．７％。重度异型增生表达率显著高于早期胃癌（Ｐ＜０．０５），进展期胃癌表达率显著高于早期胃癌（Ｐ＜０．０５），淋巴结转移组的表达率高于淋巴结未转移组（Ｐ＜０．０５），但Ｐ１８５蛋白的表达与胃癌组织学类型及胃癌肿块大小无相关性（Ｐ＞０．０５）。提示：Ｐ１８５蛋白有可能参与正常胃粘膜的增殖、修复及癌变过程，Ｐ１８５蛋白阳性的肿瘤可能具有更强的浸润及转移能力。
Using monoclonal antibodies against c-erbB2 oncogene protein (P185), immunohistochemical ABC method was used to study normal gastric mucosa, gastric mucosa dysplasia, early gastric cancer and advanced gastric cancer. RESULTS: Weakly positive expression of P185 protein was found in the neck of normal gastric mucosa glands. The expression rate of P185 protein in mild, moderate and severe dysplasia was 50%, 83.3%, and 85.7%, respectively; The expression rates of P185 protein in early and advanced gastric cancer were 22.2% and 56.7%, respectively. The expression rate of severe dysplasia was significantly higher than that of early gastric cancer (P<0.05). The expression rate of advanced gastric cancer was significantly higher than that of early gastric cancer (P<0.05). The expression rate of lymph node metastasis was higher than that of lymph node metastasis (P). <0.05), but there was no correlation between the expression of P185 protein and the histological type of gastric cancer and the size of tumor (P>0.05). Tip: P185 protein may participate in the proliferation, repair and carcinogenesis of normal gastric mucosa. P185 protein-positive tumor may have stronger infiltration and metastasis capacity.