有丝分裂纺锤体检查点是确保染色体正确分离的重要信号转导通路,因此被建议作为抗癌治疗的新靶点。Kaestner等探索出以纳米粒子为基础的RNA干扰方法,针对关键纺锤体检查点MAD2基因来研究其作为体外和体内治疗靶点的适用性。结果显示:抑制MAD2会导致与结肠癌有关的、严重的染色体错误分离。由纳米介导的siRNA能减缓裸鼠异种移植瘤的生 Mitotic spindle checkpoint is an important signal transduction pathway to ensure the correct separation of chromosomes, so it is suggested as a new target for anti-cancer therapy. Kaestner et al. Explored a nanoparticle-based RNA interference approach to investigate the applicability of the MAD2 gene as a key spindle checkpoint as a therapeutic target in vitro and in vivo. The results show that: inhibition of MAD2 can lead to colon cancer-related, severe chromosomal error separation. Nano-mediated siRNA attenuates xenografts in nude mice