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目的 :了解肾综合征出血热 (HFRS)患者血清C反应蛋白 (CRP)的动态变化 ,探讨其在HFRS发病中的意义。方法 :用速率比浊法检测 39例HFRS患者和 39例正常人血清CRP含量。结果 :HFRS患者血清CRP水平明显高于对照组 (P <0 0 1 ) ,且于发热早期已增高 ,低血压期、少尿期达高峰 ,多尿期、恢复期逐渐下降至正常水平。危重型患者发热期、低血压期、少尿期较轻型、中型患者血清CRP水平明显增高(P <0 0 1 )。HFRS患者CRP水平与血小板计数呈明显负相关 (P <0 0 1 ) ,与尿蛋白、BUN呈明显正相关 (P <0 0 1 )。结论 :HFRS患者血清CRP水平与病程进展和病情轻重密切相关 ,早期动态检测对估计病情和判断预后有重要意义。
Objective: To understand the dynamic changes of serum C-reactive protein (CRP) in patients with hemorrhagic fever with renal syndrome (HFRS) and to explore its significance in the pathogenesis of HFRS. Methods: The turbidimetric method was used to detect CRP levels in 39 patients with HFRS and 39 normal controls. Results: Serum CRP levels in patients with HFRS were significantly higher than those in the control group (P <0.01). The levels of CRP in HFRS patients were higher in the early period of fever, peaked in the period of hypotension and oliguria, and gradually decreased to the normal level in the period of polyuria and convalescence. Serum CRP levels were significantly higher in critically ill patients during fever, hypotension, and oliguria (P <0.01). CRP levels in HFRS patients were negatively correlated with platelet counts (P <0.01), but positively correlated with urine protein and BUN (P <0.01). Conclusion: Serum CRP levels in patients with HFRS are closely related to the course of disease and the severity of illness. Early dynamic examination is of great significance in estimating disease status and prognosis.