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目的观察脑心通胶囊治疗高血压伴动脉粥样硬化患者的临床效果。方法将89例高血压伴动脉粥样硬化患者随机分为观察组45例和对照组44例。2组均执行原有降压方案,在此基础上,对照组加服阿托伐他汀钙片,观察组加服阿托伐他汀钙片和步长脑心通胶囊,观察组2组血压、血脂及hs-CRP、IMT、血管内皮功能变化。结果与治疗前比较,对照组TC、观察组TC、LDL-C、舒张压水平均明显下降;治疗后观察组TC、LDL-C及舒张压水平均低于对照组,差异有统计学意义(P<0.05)。2组治疗前后HDL水平变化不明显,差异无统计学意义(P>0.05)。治疗后2组hs-CRP、IMT、v WF、ET-1均低于治疗前,NO、FMD均高于治疗前;治疗后观察组hs-CRP、NO、IMT、FMD水平变化幅度大于对照组,差异均有统计学意义(P<0.05或P<0.01)。2组NMD治疗前后变化不明显(P>0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论脑心通胶囊治疗高血压伴动脉粥样硬化能有效地改善血管损伤,改善血管内皮功能。
Objective To observe the clinical effect of Naoxintong capsule on patients with hypertension and atherosclerosis. Methods Eighty-nine patients with hypertension and atherosclerosis were randomly divided into observation group (45 cases) and control group (44 cases). The two groups were the implementation of the original antihypertensive program, on this basis, the control group plus atorvastatin calcium, the observation group plus atorvastatin calcium tablets and step Tongxutongxin capsules, the observation group 2 blood pressure, Blood lipids and hs-CRP, IMT, vascular endothelial function changes. Results Compared with those before treatment, the levels of TC, LDL-C and diastolic blood pressure in the control group and the observation group decreased significantly. The levels of TC, LDL-C and diastolic blood pressure in the observation group were lower than those in the control group after treatment P <0.05). There was no significant difference in HDL levels between the two groups before and after treatment (P> 0.05). The levels of hs-CRP, NO, IMT and FMD in the two groups after treatment were lower than those before treatment, and the levels of NO and FMD in the two groups were significantly higher than those before treatment , The differences were statistically significant (P <0.05 or P <0.01). The changes of NMD before and after 2 groups were not obvious (P> 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Naoxintong capsule treatment of hypertension with atherosclerosis can effectively improve vascular injury and improve vascular endothelial function.