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目的观察胞二磷胆碱、纳洛酮配合高压氧对急性一氧化碳中毒迟发性脑病(DEACMP)的治疗效果。方法选取2002年1月至2006年12月住院的21例DEACMP患者给予高压氧治疗每天一次,胞二磷胆碱0.75 g+5%GS 250 ml或0.9%NS 250 ml及纳洛酮2.0 mg+5%GS 250 ml或0.9%NS 250 ml静滴,每天一次,14 d为一个疗程,间隔3~5 d,行第二疗程治疗。结果6例患者在第一疗程结束后症状基本消失,9例患者在第二疗程结束后症状基本消失,部分病人在出院后能胜任原有工作。结论胞二磷胆碱纳洛酮及高压氧配合治疗DEACMP疗效显著,值得临床推广应用。
Objective To observe the therapeutic effect of citicoline and naloxone combined with hyperbaric oxygen on acute delayed carbon monoxide poisoning (DEACMP). Methods Twenty-one patients with DEACMP who were hospitalized from January 2002 to December 2006 were treated with hyperbaric oxygen once a day. Citricoline 0.75 g + 5% GS 250 ml or 0.9% NS 250 ml and naloxone 2.0 mg + 5% GS 250 ml or 0.9% NS 250 ml intravenously once daily for 14 days for a course of treatment, an interval of 3 ~ 5 d, the second course of treatment. Results The symptoms disappeared in the 6 patients after the first course of treatment. The symptoms disappeared in 9 patients after the second course of treatment. Some patients were discharged after discharge. CONCLUSION: Citricoline and naloxone combined with hyperbaric oxygen are effective in treating DEACMP, which is worthy of clinical application.