Objective:This study aims to explore the association between the density of Himalayan marmot (Marmota himalayana) and climatic factors such as temperature, precipitation, humidity, vapour pressure, sunshine percentage, wind velocity, which are closely associated with global climate change, and to provide a reference for plague prevention and control. Methods: We conducted a regression analysis to find the possible climate factors associated with the density of Himalaya marmot, and analyzed the response characters of Himalayan marmot to climate change.Results: Dailyprecipitation days(>=0.1 mm) and sunshine percentage were significantly associated with thedensityofHimalayan marmot(p<0.01). Conclusion: Climate change was associated with the risk of plague. This phenomenon is valuable for Himalayan marmot and plague prevention. More studies are needed to understand the impact of climate change on Himalayan marmot and plague. Objective: This study aims to explore the association between the density of Himalayan marmot (Marmota himalayana) and climatic factors such as temperature, precipitation, humidity, vapor pressure, sunshine percentage, wind velocity, which are closely associated with global climate change, and to provide a reference for plague prevention and control. Methods: We conducted a regression analysis to find the possible climate factors associated with the density of Himalaya marmot, and analyzed the response characters of Himalayan marmot to climate change. Results: Dailyprecipitation days (> = 0.1 mm) and sunshine percentage were significantly associated with the intensity of Himalayan marmot (p <0.01). Conclusion: Climate change was associated with the risk of plague. This phenomenon is valuable for Himalayan marmot and plague prevention. More studies are needed to understand the impact of climate change on Himalayan marmot and plague.