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目的:观察复方苦参注射液配合动脉栓塞化疗治疗肝癌的疗效及不良反应。方法:将60例肝癌患者随机分为复方苦参注射液配合动脉栓塞化疗组(试验组,30例)和仅用动脉栓塞化疗组(对照组,30例),2周为1个疗程,治疗3个疗程。结果:试验组30例获部分缓解(PR)15例,稳定(SD)11例,总有效率为50.0%;对照组30例获PR 14例,SD 9例,总有效率为46.7%;两组疗效比较无显著性差异(P>0.05)。试验组白细胞下降的发生率、消化道反应(恶心呕吐、发热、肝区胀痛)发生率和肝脏毒性显著少于对照组(P<0.05)。结论:复方苦参注射液能够减轻肝癌动脉栓塞化疗不良反应,增加患者化疗耐受性,提高生活质量。
Objective: To observe the efficacy and side effects of compound Kushen injection combined with arterial embolization chemotherapy in the treatment of liver cancer. Methods: Sixty liver cancer patients were randomly divided into compound Kushen injection with arterial embolization chemotherapy (experimental group, 30 cases) and arterial embolization chemotherapy group (control group, 30 cases), 2 weeks for a course of treatment, treatment 3 courses. Results: In the experimental group, 15 cases were partially relieved (PR) and 11 cases were stable (SD), the total effective rate was 50.0%. In the control group, 30 cases were PR 14 and SD 9 cases, the total effective rate was 46.7% There was no significant difference between the two groups (P> 0.05). The incidence of leukopenia and the incidence of digestive tract reactions (nausea, vomiting, fever, liver pain) and liver toxicity in the experimental group were significantly less than those in the control group (P <0.05). Conclusion: Compound Kushen injection can reduce the adverse reactions of chemoembolization of arterial embolism in patients with hepatocellular carcinoma, increase the patient’s tolerance to chemotherapy and improve the quality of life.